Journal
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
Volume 40, Issue 10, Pages 1078-1081Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/apnm-2015-0158
Keywords
insulin-dependent diabetes mellitus; oxidative stress; brain mitochondria protocatechuic acid
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Funding
- Thailand Research Fund [BRG5780016, TRG5880045]
- NSTDA Research Chair Grant from the National Science and Technology Development Agency
- Chiang Mai University Center of Excellence Award
- Faculty of Medicine Endowment Fund, Chiang Mai University
- Udon Thani Rajabhat University Fund
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Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, has been shown to exert glycemic control and oxidative stress reduction in the heart. However, its effects on oxidative stress and mitochondrial function in the brain under diabetic condition have never been investigated. We found that PCA exerted glycemic control, attenuates brain mitochondrial dysfunction, and contributes to the prevention of brain oxidative stress in diabetic rats.
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