Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 41, Pages 12830-12833Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1511904112
Keywords
hippocampus; developmental amnesia; recall; recognition
Categories
Funding
- Medical Research Council [G03000117/65439]
- Central and East London Research Network [5177]
- Intramural Research Program of the National Institute of Mental Health, National Institutes of Health
- MRC [G1002276, G0300117] Funding Source: UKRI
- Medical Research Council [G0300117, G1002276] Funding Source: researchfish
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Which specific memory functions are dependent on the hippocampus is still debated. The availability of a large cohort of patients who had sustained relatively selective hippocampal damage early in life enabled us to determine which type of mnemonic deficit showed a correlation with extent of hippocampal injury. We assessed our patient cohort on a test that provides measures of recognition and recall that are equated for difficulty and found that the patients' performance on the recall tests correlated significantly with their hippocampal volumes, whereas their performance on the equally difficult recognition tests did not and, indeed, was largely unaffected regardless of extent of hippocampal atrophy. The results provide new evidence in favor of the view that the hippocampus is essential for recall but not for recognition.
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