Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 47, Pages 14444-14451Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1516247112
Keywords
biomaterials; soft materials; feature control; dynamics; biocomplex
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Funding
- National Institutes of Health (National Heart, Lung, and Blood Institute) through a Ruth L. Kirschstein National Research Service Award [F32HL122009]
- American Heart Association (AHA) through an AHA Predoctoral Fellowship [14PRE20130045]
- National Institutes of Health [R01HL111090, R01EB008722, R01AR056624, R01DE016523]
- National Science Foundation [DMR1006711]
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Biomaterials that interface with biological systems are used to deliver drugs safely and efficiently; to prevent, detect, and treat disease; to assist the body as it heals; and to engineer functional tissues outside of the body for organ replacement. The field has evolved beyond selecting materials that were originally designed for other applications with a primary focus on properties that enabled restoration of function and mitigation of acute pathology. Biomaterials are now designed rationally with controlled structure and dynamic functionality to integrate with biological complexity and perform tailored, high-level functions in the body. The transition has been from permissive to promoting biomaterials that are no longer bioinert but bioactive. This perspective surveys recent developments in the field of polymeric and soft biomaterials with a specific emphasis on advances in nano-to macroscale control, static to dynamic functionality, and biocomplex materials.
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