Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 39, Pages 12005-12010Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1515882112
Keywords
HDAC; tubulin; cancer
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Funding
- National Institute of Cancer [P30CA08748-44]
- David Koch Foundation
- Servier
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We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.
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