Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 33, Pages 10521-10526Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1508785112
Keywords
hippocampus; mouse; optogenetics; ripples; temporal precision
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Funding
- Rothschild Foundation
- Human Frontiers in Science Program [LT-000346/2009-L]
- Machiah Foundation [20090098]
- National Institutes of Health [MH54671, MH102840, NS074015]
- Mathers Foundation
- Human Frontier Science Program
- National Science Foundation (Temporal Dynamics of Learning Center Grant) [SBE 0542013]
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Sequential activity of multineuronal spiking can be observed during theta and high-frequency ripple oscillations in the hippocampal CA1 region and is linked to experience, but the mechanisms underlying such sequences are unknown. We compared multineuronal spiking during theta oscillations, spontaneous ripples, and focal optically induced high-frequency oscillations (synthetic ripples) in freely moving mice. Firing rates and rate modulations of individual neurons, and multineuronal sequences of pyramidal cell and interneuron spiking, were correlated during theta oscillations, spontaneous ripples, and synthetic ripples. Interneuron spiking was crucial for sequence consistency. These results suggest that participation of single neurons and their sequential order in population events are not strictly determined by extrinsic inputs but also influenced by local-circuit properties, including synapses between local neurons and single-neuron biophysics.
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