Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 41, Pages 12846-12851Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1505068112
Keywords
fear extinction; olfaction; neural plasticity
Categories
Funding
- National Institutes of Mental Health [1R01MH096764]
- Howard Hughes Medical Institute
- Ruth L. Kirstein National Research Service Award (NRSA) Predoctoral Fellowship [F31 MH105237-01]
- Office of Research Infrastructure Programs [OD P51OD011132, P51RR000165]
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Although much work has investigated the contribution of brain regions such as the amygdala, hippocampus, and prefrontal cortex to the processing of fear learning and memory, fewer studies have examined the role of sensory systems, in particular the olfactory system, in the detection and perception of cues involved in learning and memory. The primary sensory receptive field maps of the olfactory system are exquisitely organized and respond dynamically to cues in the environment, remaining plastic from development through adulthood. We have previously demonstrated that olfactory fear conditioning leads to increased odorant-specific receptor representation in the main olfactory epithelium and in glomeruli within the olfactory bulb. We now demonstrate that olfactory extinction training specific to the conditioned odor stimulus reverses the conditioning-associated freezing behavior and odor learning-induced structural changes in the olfactory epithelium and olfactory bulb in an odorant ligand-specific manner. These data suggest that learning-induced freezing behavior, structural alterations, and enhanced neural sensory representation can be reversed in adult mice following extinction training.
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