4.1 Article

HIV-Exposed Uninfected Infants are at Increased Risk for Severe Infections in the First Year of Life

Journal

JOURNAL OF TROPICAL PEDIATRICS
Volume 58, Issue 6, Pages 505-508

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/tropej/fms019

Keywords

HIV-exposed infants; HIV; vertical transmission prevention; PMTCT; South Africa

Funding

  1. Immunology and Virology units at the National Health Laboratory Service
  2. Tygerberg Hospital
  3. Children's Infectious Diseases Clinical Research Unity (KID-CRU)
  4. National Institutes of Health [N01 A150023]
  5. British Columbia Children's Hospital Foundation
  6. Martha Piper Fund
  7. Peter Wall Institute for Advanced Studies
  8. National Health Laboratory Service [TY94171, KNC97, KNC103]
  9. Poliomyelitis Research Foundation [10/02, 10/31, 11/37]
  10. Harry Crossley Foundation [5415, 5762]
  11. Canadian Institutes of Health Research
  12. Michael Smith Foundation for HEalth Research
  13. Burroughs Wellcome Fund in partnership with SickKids Foundation
  14. Child & Family Research Institute (BC)
  15. Women & Children's Health Research Institute (Alberta)
  16. Manitoba Institute of Child Health
  17. Sauder Family Professorship

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HIV-exposed uninfected (HEU) infants have higher infectious morbidity than HIV-unexposed uninfected (HUU) infants. We present the clinical outcomes from a pilot cohort study of 27 HEU and 28 HUU infants. In the absence of infant malnutrition or advanced maternal HIV, HEU infants experienced a 2.74 (0.85-8.78) times greater risk of hospitalization in the first year.

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