Journal
JOURNAL OF TROPICAL PEDIATRICS
Volume 58, Issue 1, Pages 68-70Publisher
OXFORD UNIV PRESS
DOI: 10.1093/tropej/fmr032
Keywords
typhoid fever; nucleic acid amplification test; rapid diagnostic test; blood culture; children
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Funding
- OAK foundation through Oxford University
- Wellcome Trust
- Li Ka Shing Foundation
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Typhoid fever was confirmed by positive blood culture in 5 (3.7%) of 134 febrile children hospitalized in Cambodia. Typhoid was suspected in an additional 25 (18.7 %) blood culture-negative children based on: a positive immunoglobulin M lateral flow assay (IgMFA) (16); a positive polymerase chain reaction (PCR) for Salmonella typhi (2); or clinical assessment (7). The specificity of the IgMFA and PCR assays requires further study.
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