Journal
JOURNAL OF TROPICAL PEDIATRICS
Volume 56, Issue 4, Pages 242-246Publisher
OXFORD UNIV PRESS
DOI: 10.1093/tropej/fmp101
Keywords
respiratory syncytial virus; association study; single nucleotide polymorphism; IL-8; allele-specific polymerase chain reaction
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Funding
- Children's Hospital of Fudan University
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Methods: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele's frequencies of SNPs were analyzed with case-control study, linkage of two loci and haplotypes composed by the two loci were also studied. Results: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01). Conclusion: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.
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