Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12967-014-0219-9
Keywords
Oleuropein; Hydroxytyrosol; Virgin olive oil; Phenols; Antioxidant; Cardiovascular disease; Diabetes mellitus
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Funding
- MIUR [2010NFEB9L_003, RBFR12FI27_003]
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The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders. The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.
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