Journal
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Volume 50, Issue -, Pages 384-392Publisher
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2018.08.003
Keywords
Element homeostasis; Hexavalent chromium exposure; Serum lipoprotein metabolism
Funding
- National Natural Science Foundation of China [81072281, 81273043, 81573118, 81673118]
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Objective: To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism. Methods: One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins. Results: The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0.05). The levels of serum TG, FPG, LDL-C, Apo AI, AII, CII, CIII, E and Lp(a) also changed significantly (P < 0.05). Concentration of chromium in whole blood and erythrocytes had different relationships with serum apolipoprotein levels in Cr(VI)exposed subjects. Conclusions: Exposure of hexavalent chromium could significantly change the homeostasis of multi-elements as well as the levels of serum apolipoproteins. Cr(III) and Cr(VI)may have different effects on the apolipoproteins.
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