Journal
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
Volume 77, Issue 1-3, Pages 69-79Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15287394.2014.865584
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Brazil)
- Conselho Nacional de desenvolvimento Cientifico e Tecnologico (CNPq - Brazil)
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This study aimed to determine the concentrations of plasma methylmercury (Me-Hg) and inorganic mercury (I-Hg) in a population exposed to Me-Hg. In addition, associations between each form of mercury (Hg) and gender, age, plasma selenium (Se), and oxidative stress markers were also investigated. The mean plasma I-Hg level was 5.7 g/L while the mean for plasma Me-Hg was 3.6 g/L, representing approximately 59 and 41% of the total Hg in blood, respectively. However, several plasma samples contained higher percentages of Me-Hg. Age displayed a direct linkage with plasma I-Hg levels, whereas gender did not correlate with any of the Hg species. In addition, fish intake was only correlated with and a predictor of plasma Me-Hg, suggesting that plasma I-Hg levels originated endogenously through a demethylation reaction that needs to be verified. Further, plasma Me-Hg was markedly correlated with adverse effects to a greater extent than plasma I-Hg and may be considered a valuable, reliable internal dose biomarker for Hg in chronically Me-Hg- exposed individuals.
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