Journal
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
Volume 74, Issue 2-4, Pages 146-153Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15287394.2011.529064
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS060034] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS060034] Funding Source: Medline
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Global gene expression analysis allows for the identification of transcripts that are differentially regulated during a disease state. Many groups, including our own, have identified hundreds of genes differentially regulated in response to prion infection. Eleven transcripts, upregulated in the brains of prion-infected animals, which were classified in the literature as stimulated by the cytokine interferon-gamma (IFN-gamma), were identified. This is intriguing, as IFN-gamma has recently been detected in the brains of prion-infected animals. Quantitation of several genes, categorized as IFN-gamma inducible, by quantitative real-time polymerase chain reaction (qRT-PCR) confirms that these transcripts are upregulated. Future approaches for delineating the role of IFN-gamma-induced transcripts and their function in prion infection are described.
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