Journal
JOURNAL OF TOXICOLOGICAL SCIENCES
Volume 35, Issue 1, Pages 125-129Publisher
JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.35.125
Keywords
Nickel chloride; Sacchromyces cerevisiae; DNA microarray
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Funding
- Japan Society for the Promotion of Science
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In order to investigate nickel toxicity against the yeast Saccharomyces cerevisiae, genomic responses to nickel chloride were examined using yeast DNA microarrays. Microarray analysis revealed that exposure to 25 mM nickel chloride for 2 hr induced changes in gene expression in S. cerevisiae. Nickel chloride increased expression levels in 601 genes and decreased expression levels in 696 genes in S. cerevisiae.
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