Journal
JOURNAL OF TOXICOLOGICAL SCIENCES
Volume 34, Issue 3, Pages 349-354Publisher
JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.34.349
Keywords
FePt nanoparticle; 2-aminoethanethiol; Cysteamine; Genotoxicity; Bacterial reverse mutation assay; Chromosomal aberration test
Categories
Funding
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
Ask authors/readers for more resources
Genotoxicity of superparamagnetic iron-platinum (Feet) nanoparticles (NPs) capped with 2-aminoethanethiol (AET) was evaluated using the bacterial reverse mutation assay (Ames test) and in vitro chromosomal aberration test. Mutagenicity of AET-capped FePt NPs was found to be negative in the Ames test, while elastogenicity of FePt NPs seemed to be false-positive in the in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells. However, further detailed in vitro genotoxicity tests, such as DNA adduct studies, are necessary to conclude that a positive aberration result is irrelevant.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available