Journal
JOURNAL OF TOXICOLOGICAL SCIENCES
Volume 33, Issue 3, Pages 293-298Publisher
JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.33.293
Keywords
titanium dioxide; nanoparticle; absorption; elimination
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If titanium dioxide nanoparticles are inert and non-biodegradable, they must be evaluated similarly to fullerenes, carbon nanotubes and asbestos. We surveyed the titanium level in typical raw food materials, and then intravenously injected titanium dioxide nanoparticles (primary particle diameter: 15 nm; secondary particle size: 220 nm) in mice and determined their tissue distribution and elimination. As a result, an unexpectedly high titanium concentration was observed in several foods. It was also detected in blood and tissues of healthy mice without administration of titanium dioxide nanoparticles. Then, forced i.v. injection of the nanoparticles was performed in mice. The titanim level was significantly increased in blood and tissues, but no increase was found in the brain after i.v. injection. Most titanium was concentration in the liver after injection, but the liver level decreased over time (ca. 30% decrease in 1 month). These date show that titanium must be eliminated from the body, and suggest that we should reconsider an evaluation method for toxicity of titanium dioxide nanoparticles.
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