Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 2, Issue 6, Pages 378-380Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/term.106
Keywords
chitosan microparticles; injectable scaffolds; stem cells; tissue engineering; minimally invasive surgical procedures
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Funding
- Generalitat Valenciana [BEFPI/2007/012]
- Spanish Ministry of Science [MAT2007-66759-C03-01]
- European Union [NMP3-CT-2003-505758]
- European NoE EXPERTISSUES [NMP3-CT-2004-500283]
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The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine. Copyright (C) 2008 John Wiley & Sons, Ltd.
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