Related references
Note: Only part of the references are listed.Receptor of Activated Protein C Promotes Metastasis and Correlates with Clinical Outcome in Lung Adenocarcinoma
Iker Anton et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)
The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein-Coupled Receptors
Celine Valant et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)
Molecular Mechanism of beta-Arrestin-Biased Agonism at Seven-Transmembrane Receptors
Eric Reiter et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)
sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove
Jacinto Lopez-Sagaseta et al.
BLOOD (2012)
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes
Thati Madhusudhan et al.
BLOOD (2012)
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
Laurent O. Mosnier et al.
BLOOD (2012)
A new era of GPCR structural and chemical biology
Sebastien Granier et al.
NATURE CHEMICAL BIOLOGY (2012)
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor
Carrie R. Willcox et al.
NATURE IMMUNOLOGY (2012)
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity
Hartmut Geiger et al.
NATURE MEDICINE (2012)
Targeting proteinase-activated receptors: therapeutic potential and challenges
Rithwik Ramachandran et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Drotrecogin Alfa (Activated) in Adults with Septic Shock
V. Marco Ranieri et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR
Jeffrey J. Liu et al.
SCIENCE (2012)
Protein C anticoagulant system-anti-inflammatory effects
Charles T. Esmon
SEMINARS IN IMMUNOPATHOLOGY (2012)
The anticoagulant function of coagulation factor V
Thomas J. Cramer et al.
THROMBOSIS AND HAEMOSTASIS (2012)
Is EPCR a multi-ligand receptor? Pros and cons
Ramon Montes et al.
THROMBOSIS AND HAEMOSTASIS (2012)
The protein C pathway in cancer metastasis
C. Arnold Spek et al.
THROMBOSIS RESEARCH (2012)
Diversity and modularity of G protein-coupled receptor structures
Vsevolod Katritch et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Protease Activated Receptor-2 Mediates Activated Protein C-Induced Cutaneous Wound Healing via Inhibition of p38
Sohel M. Julovi et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa-Induced Lung Injury in Mice
Nastasha Bir et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C
Prosenjit Sen et al.
BLOOD (2011)
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
Prosenjit Sen et al.
BLOOD (2011)
Biased Ligands for Better Cardiovascular Drugs Dissecting G-Protein-Coupled Receptor Pharmacology
Scott M. DeWire et al.
CIRCULATION RESEARCH (2011)
Multiple receptor-mediated functions of activated protein C
H. Weiler
HAMOSTASEOLOGIE (2011)
The Occupancy of Endothelial Protein C Receptor by its Ligand Modulates the PAR-1 Dependent Signaling Specificity of Coagulation Proteases
Alireza R. Rezaie
IUBMB LIFE (2011)
The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors
Jennifer Disse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds
Unice J. K. Soh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The structure-function relationship of activated protein C Lessons from natural and engineered mutations
Karin C. A. A. Wildhagen et al.
THROMBOSIS AND HAEMOSTASIS (2011)
Cytoprotective protein C pathways and implications for stroke and neurological disorders
Berislav V. Zlokovic et al.
TRENDS IN NEUROSCIENCES (2011)
Phospholipase A(2)s: Developing drug targets for atherosclerosis
Keith Suckling
ATHEROSCLEROSIS (2010)
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
Silvio Danese et al.
BLOOD (2010)
Lipoprotein-Associated and Secreted Phospholipases A2 in Cardiovascular Disease Roles as Biological Effectors and Biomarkers
Ziad Mallat et al.
CIRCULATION (2010)
Regulation of inflammation by the protein C system
Hartmut Weiler
CRITICAL CARE MEDICINE (2010)
Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways
A. R. Rezaie
CURRENT MEDICINAL CHEMISTRY (2010)
Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function
Nikita Minhas et al.
FASEB JOURNAL (2010)
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
Chunzhang Cao et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
APC resistance: biological basis and acquired influences
E. Castoldi et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa)
R. Gopalakrishnan et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor
R. A. Schuepbach et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
Ramesh C. Nayak et al.
BLOOD (2009)
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement
Geerte L. Van Sluis et al.
BLOOD (2009)
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
Laurent O. Mosnier et al.
BLOOD (2009)
Role of activated protein C and its receptor in inhibition of tumor metastasis
Michael Bezuhly et al.
BLOOD (2009)
Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis
Eric Yang et al.
CANCER RESEARCH (2009)
Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways
Mario Menschikowski et al.
EXPERIMENTAL CELL RESEARCH (2009)
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier
Rashid Deane et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)
Proteases Display Biased Agonism at Protease-Activated Receptors: Location Matters!
Angela Russo et al.
MOLECULAR INTERVENTIONS (2009)
The role of dynamic conformational ensembles in biomolecular recognition
David D. Boehr et al.
NATURE CHEMICAL BIOLOGY (2009)
Extracellular histones are major mediators of death in sepsis
Jun Xu et al.
NATURE MEDICINE (2009)
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells
Xia V. Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Caveolae are required for protease-selective signaling by protease-activated receptor-1
Angela Russo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1
Xiaochun Li et al.
BLOOD (2008)
Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement
Shona Harmon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V
Andrew J. Gale et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
J. -S. Bae et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
Reto A. Schuepbach et al.
BLOOD (2008)
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a banier-protective response in endothelial cells
Jong-Sup Bae et al.
BLOOD (2007)
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
Nicole C. Kaneider et al.
NATURE IMMUNOLOGY (2007)
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
Berend Isermann et al.
NATURE MEDICINE (2007)
Protein C and its inhibitor in malignancy
Koji Suzuki et al.
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2007)
Endotoxemia and sepsis mortality reduction by non-anticoagulant-activated protein C
Edward J. Kerschen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Binding of factor Vila to the endothelial cell protein C receptor reduces its coagulant activity
J. Lopez-Sagaseta et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1
Likui Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
Samit Ghosh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
Joseph N. McLaughlin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties
Jong-Sup Bae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells
Jong-Sup Bae et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1
Lea M. Beaulieu et al.
EXPERIMENTAL CELL RESEARCH (2007)
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-α converting enzyme/ADAM17
D. Qu et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Protease-activated receptors in hemostasis, thrombosis and vascular biology
SR Coughlin
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin
W Li et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)
Regulation of blood coagulation by the protein C anticoagulant pathway -: Novel insights into structure-function relationships and molecular recognition
B Dahlbäck et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
M Riewald et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Activated protein C mediates novel lung endothelial barrier enhancement - Role of sphingosine 1-phosphate receptor transactivation
JH Finigan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
C Feistritzer et al.
BLOOD (2005)
Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
RJS Preston et al.
FEBS JOURNAL (2005)
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
H Guo et al.
NEURON (2004)
The discovery of thrombomodulin
CT Esmon et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
LO Mosnier et al.
BLOOD (2004)
The crystal structure of the endothelial protein C receptor and a bound phospholipid
V Oganesyan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Expression of the vascular endothelial cell protein C receptor in epithelial tumour cells
GL Scheffer et al.
EUROPEAN JOURNAL OF CANCER (2002)
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
M Riewald et al.
SCIENCE (2002)
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
DE Joyce et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Efficacy and safety of recombinant human activated protein C for severe sepsis.
GR Bernard et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Thrombin signalling and protease-activated receptors
SR Coughlin
NATURE (2000)
Thrombin responses in human endothelial cells - Contributions from receptors other than Par1 include the transactivation of Par2 by thrombin-cleaved Par1
PJ O'Brien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function
PCY Liaw et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Metalloproteolytic release of endothelial cell protein C receptor
J Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
