Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 10, Issue 2, Pages 177-188Publisher
WILEY
DOI: 10.1111/j.1538-7836.2011.04571.x
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Funding
- Kay Kendall Leukaemia Fund Travelling Fellowship
- Fulbright Scholarship in Cancer Research
- NCI
- Children's Cancer and Blood foundation
- Stavros S. Niarchos Foundation
- Champalimaud Foundation
- Nancy C. and Daniel P. Paduano Foundation
- Hartwell Foundation
- Witmer Family Foundation
- Malcolm Hewitt Wiener Foundation
- Mary Kay Ash Charitable Foundation
- AHEPA 5th District
- National Foundation for Cancer Research
- Susan G. Komen for the Cure
- Leukaemia & Lymphoma Research Specialist Programme [08030]
- Imperial College London Comprehensive Biomedical Research Centre
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. Dynamic interactions between hematopoietic cells and their specialized bone marrow microenvironments, namely the vascular and osteoblastic niches, regulate hematopoiesis. The vascular niche is conducive for thrombopoiesis and megakaryocytes may, in turn, regulate the vascular niche, especially in supporting vascular and hematopoietic regeneration following irradiation or chemotherapy. A role for platelets in tumor growth and metastasis is well established and, more recently, the vascular niche has also been implicated as an area for preferential homing and engraftment of malignant cells. This article aims to provide an overview of the dynamic interactions between cellular and molecular components of the bone marrow vascular niche and the potential role of megakaryocytes in bone marrow malignancy.
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