Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 10, Issue 9, Pages 1722-1732Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1538-7836.2012.04837.x
Keywords
calcium; connexins; ion channels; ionotropic glutamate receptors; K plus channels; megakaryocytes; membrane potential; Orai1; P2X1; platelets
Categories
Funding
- British Heart Foundation [PG/11/56, PG/11/125]
- British Heart Foundation [PG/11/56/29001] Funding Source: researchfish
Ask authors/readers for more resources
. Ion channels are transmembrane proteins that play ubiquitous roles in cellular homeostasis and activation. In addition to their recognized role in the regulation of ionic permeability and thus membrane potential, some channel proteins possess intrinsic kinase activity, directly interact with integrins or are permeable to molecules up to similar to 1000 Da. The small size and anuclear nature of the platelet has often hindered progress in understanding the role of specific ion channels in hemostasis, thrombosis and other platelet-dependent events. However, with the aid of transgenic mice and surrogate patch clamp recordings from primary megakaryocytes, important unique contributions to platelet function have been identified for several classes of ion channel. Examples include ATP-gated P2X1 channels, Orai1 store-operated Ca2+ channels, voltage-gated Kv1.3 channels, AMPA and kainate glutamate receptors and connexin gap junction channels. Furthermore, evidence exists that some ion channels, such as NMDA glutamate receptors, contribute to megakaryocyte development. This review examines the evidence for expression of a range of ion channels in the platelet and its progenitor cell, and highlights the distinct roles that these proteins may play in health and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available