Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 7, Issue -, Pages 206-209Publisher
WILEY
DOI: 10.1111/j.1538-7836.2009.03370.x
Keywords
calcium; integrin; kindlin-3; platelet; talin
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Heterodimeric receptors of the beta 1 and beta 3 integrin families mediate platelet adhesion and aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a low-affinity state but they shift to a high-affinity state and efficiently bind their ligands in response to cellular activation. This review summarizes recent advances in understanding the functional regulation and (patho-) physiological significance of individual platelet integrins with a special focus on studies in genetically modified mice. It is now recognized that beta 1 and beta 3 integrins have partially redundant roles in the adhesion process and that their activation is regulated by similar mechanisms, involving Ca2+-dependent and -independent signaling events and essential functions of talin-1 and kindlin-3 in the terminal activation step.
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