Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 6, Issue 6, Pages 969-975Publisher
WILEY
DOI: 10.1111/j.1538-7836.2008.02954.x
Keywords
animal model; hemophilia; joint bleeding; murine; recombinant factor VIIa; recombinant factor VIII
Categories
Ask authors/readers for more resources
Background: Hemophilia A is the most common serious bleeding disorder, and the hallmark of this disease is joint bleeding episodes. These result in hemophilic synovitis, an inflammatory and proliferative condition of the joint, which progresses into a chronic degenerative arthritis, hemophilic arthropathy. Methods: In this paper, we describe the effect of recombinant factor VIIa (rFVIIa), and an analogue NN1731 as well as rFVIII on needle-induced bleeding in hemophilia A mice. Conclusions: Here we show a reducing effect of rFVIIa and NN1731 on bleeding induced in hemophilic mice, and we show that preventive treatment with rFVIII normalizes bleeding.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available