Journal
PROCEEDINGS OF THE IEEE
Volume 103, Issue 11, Pages 2196-2207Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JPROC.2015.2443832
Keywords
Boolean; digital; genetic; logic; synthesis; synthetic biology; transcription
Categories
Funding
- National Science Foundation [1147158, 1253856]
- Air Force Academy Faculty Pipeline Fellowship
- Office of Naval Research (ONR) [N00014-13-1-0074]
- National Institutes of Health [GMO98792]
- National Science Foundation Synthetic Biology Engineering Research Center (SynBERC) [EEC0540879]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1147158] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1253856] Funding Source: National Science Foundation
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Digital electronic circuits have inspired synthetic biologists to program living cells with synthetic decision-making circuits by creating multilevel genetic logic gates. In both genetic and electronic circuits, logic synthesis translates an abstract functional description into a representation that can be physically implemented. However, inherent differences in genetic logic devices present new synthesis challenges. Here we provide a starting point for a growing set of biodesign automation tools to tackle this challenge in a unified way. This framework will enable direct comparison of new approaches, results that are transferable and standardized, and research into independent areas of the problem formulation with a clear path toward future integration.
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