Journal
JOURNAL OF THERMAL BIOLOGY
Volume 35, Issue 2, Pages 105-111Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtherbio.2009.12.003
Keywords
Low temperature; Mitochondrial respiration; Electron transport system; Pyruvate dehydrogenase; Mitochondrial complexes
Funding
- Natural Sciences and Engineering Research Council of Canada
- Fonds Quebecois de la Recherche Sur la Nature et les Techologies
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To identify the most temperature-sensitive steps in the energy production pathways, we measured the thermal sensitivity of mitochondrial oxidative phosphorylation (OXPHOS), as well as that of the individual steps in this process in rat heart mitochondria. OXPHOS Measured in the presence of pyruvate+malate as Substrates have an unusually high thermal sensitivity between 5 and 15 degrees C. Furthermore, the thermal sensitivity of OXPHOS correlates with the thermal sensitivity of pyruvate dehydrogenase between 5 and 35 degrees C. Pyruvate dehydrogenase is a potential control point for pyruvate-supported mitochondrial respiration below physiological temperature in rat heart. (C) 2009 Elsevier Ltd. All rights reserved.
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