Journal
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
Volume 108, Issue 1, Pages 235-241Publisher
SPRINGER
DOI: 10.1007/s10973-011-1504-y
Keywords
Amorphous phase; Crystalline solids; DSC; Mechanical activation; Milling
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In this work, thermoanalytical, diffractometry, and microscopy measurements have been performed in order to characterize the effect of high energy milling on a drug active in the migraine prophylaxis and smoke cessation. We can assert that the mechanical treatment induces only a partial amorphisation of the solid phase, in particular it reduces the crystal order by producing lattice defects which propagate from the surface to the bulk crystal. For this reason, the DSC is able to detect the presence of ordered solid, while the powder X-ray diffractometry, because of its low penetration depth, does not reach the crystalline core of the particles.
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