Journal
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
Volume 104, Issue 1, Pages 255-260Publisher
SPRINGER
DOI: 10.1007/s10973-010-1245-3
Keywords
Compatibility; DSC; X-ray powder diffraction; Olanzapine; TGA; Solid pharmaceutical dosage forms
Funding
- CAPES
- CNPq
- FINEP
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During preformulation studies of pharmaceutical solid dosage forms, thermal analysis techniques are very useful to detect physical or chemical incompatibilities between the drug and adjuvants of interest that might interfere with efficacy and safety of the final drug product. Differential scanning calorimetry (DSC) and thermogravimetry (TG) are useful tools for this purpose. The aim of this study was to investigate the thermoanalytical behavior of olanzapine (OLZ) when mixed with several excipients commonly used in solid dosage forms such as microcrystalline cellulose, croscarmellose, dicalcium phosphate dihydrate (DCPD), lactose, magnesium stearate, and povidone. Following DSC and TG analyses, powder X-ray diffraction tests were carried out. Thermoanalytical methods showed evidence of interaction between OLZ and magnesium stearate, lactose, and povidone. These results can be useful during the selection of excipients for pharmaceutical formulation development.
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