Journal
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
Volume 97, Issue 2, Pages 729-733Publisher
SPRINGER
DOI: 10.1007/s10973-009-0282-2
Keywords
Venlafaxine hydrochloride; Solid-state characterization; Compatibility studies
Funding
- CNPq
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The thermal analytical study of venlafaxine hydrochloride, a third generation antidepressant, was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The DSC curves have shown a sharp endothermic event at 211 A degrees C and TG demonstrated a single stage of mass loss between 254 and 283 A degrees C. Solid-state characterization was carried out by DRIFT, SEM, and XRPD demonstrating the drug physicochemical properties including crystallinity. Drug-excipient compatibility studies investigated by DSC have shown a possible physical interaction of the drug with magnesium stearate, microcrystalline cellulose and starch. Nevertheless, these results where not confirmed by DRIFT and SEM analyses.
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