Journal
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
Volume 93, Issue 3, Pages 871-874Publisher
SPRINGER
DOI: 10.1007/s10973-008-9076-1
Keywords
crystal form; DA-5018; dissolution; DSC; polymorphism; pseudopolymorphism; PXRD; TG; transformation
Ask authors/readers for more resources
DA-5018 is a new capsaicin derivative and has analgesic effect. The objective of this work was to investigate the existence of polymorphs and pseudopolymorphs of DA-5018 and the transformation of crystal forms. Eight crystal forms of DA-5018 have been isolated by recrystallization and characterized by powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). The PXRD and DSC patterns of the eight crystal forms were different respectively. In the dissolution studies in simulated intestinal fluid at 37 +/- 0.5 degrees C, the solubility of Form 2 was the highest. And the solubility in water decreased in rank order: Form 2>Form 3>Form 1>Forrn 5>17orm 7>Forrn 4>Form 6>Form 8. Eight crystal forms were shown to have a good physical stability at room temperature for 60 days.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available