Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 267, Issue 4, Pages 614-625Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2010.08.017
Keywords
Signal transduction; Intracellular transport; Protein motors; Microtubules; Discontinuous Galerkin methods
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Funding
- Interdipartimental CNR
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We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules All parameters entering the models are thoroughly discussed The model is tested by numerical simulations based on discontinuous Galerkin finite element methods The numerical experiments are compared to the behavior observed experimentally (C) 2010 Elsevier Ltd All rights reserved
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