Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 266, Issue 4, Pages 708-711Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2010.07.031
Keywords
Cancer progression; Mathematical model; Feedback
Categories
Funding
- EPSRC [GR/S720231/01]
- IBM
- EPSRC DTA [EP/P500397/1]
- Cancer Research UK
- Royal Society
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It is now generally accepted that cancers contain a sub-population, the cancer stem cells (CSCs), which initiate and drive a tumour's growth. At least until recently it has been widely assumed that only a small proportion of the cells in a tumour are CSCs. Here we use a mathematical model, supported by experimental evidence, to show that such an assumption is unwarranted. We show that CSCs may comprise any possible proportion of the tumour, and that the higher the proportion the more aggressive the tumour is likely to be. (c) 2010 Elsevier Ltd. All rights reserved.
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