Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 267, Issue 2, Pages 164-170Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2010.08.019
Keywords
Genomics; Haplotype diversity; SNP; Tag SNP
Categories
Funding
- University of Tehran
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In this paper, a new efficient algorithm is presented for haplotype block partitioning based on haplotype diversity. In this algorithm, finding the largest meaningful block that satisfies the diversity condition is the main goal as an optimization problem. The algorithm can be performed in polynomial time complexity with regard to the number of haplotypes and SNPs. We apply our algorithm on three biological data sets from chromosome 21 in three different population data sets from HapMap data bulk; the obtained results show the efficiency and better performance of our algorithm in comparison with three other well known methods. (C) 2010 Elsevier Ltd. All rights reserved.
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