Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 253, Issue 1, Pages 215-219Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2008.02.027
Keywords
recycling; protein turnover; mathematical analysis
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In studies of whole body protein turnover, recycling of tracer from the breakdown of labelled protein is usually neglected; this neglect may introduce a significant error. A three-pool model with fast and slowly turning over protein pools has been used to calculate recycling rates over a range of sizes and turnover rates of the protein pools. Complete and approximate solutions of the equations are given. The recycling rate of 1% per hour would fit the available data on the turnover rates of human tissue proteins. (c) 2008 Elsevier Ltd. All rights reserved.
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