Journal
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Volume 79, Issue 8, Pages 953-964Publisher
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC130813134O
Keywords
3-(2-arylhydrazono)acetylacetone; isatin; transition metals; mixed ligands; cytotoxicity
Categories
Ask authors/readers for more resources
Complexes of the type [ML'L(OH)(H2O)], where M = Ni(II), Co(II) or Mn(II), L' = isatin and HL = 3-(2-phenylhydrazono)acetylacetone, 3-(2-(4-chlorophenyl)hydrazono)acetylacetone or 3-(2-(4-bromophenyl)hydrazono)-acetylacetone, were synthesized by equimolar reaction of a metal(II) chloride with isatin and a 3-(2-arylhydrazono)acetylacetone. The resulting complexes were characterized by elemental analyses, molar conductivity, spectral data (IR and mass spectrometry) and magnetic moments. Furthermore, the ligands and their metal complexes were screened for their cytotoxicity against different human cancer cell lines using the sulforhodamine B (SRB) assay. The results showed that most of the mixed ligand metal complexes have high cytotoxicity in comparison with the reference drugs used.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available