Journal
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Volume 76, Issue 5, Pages 647-677Publisher
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC101015064S
Keywords
EPR spectroscopy; oxidative status; antioxidants; spin-probes; spin-traps
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Funding
- Ministry of Science and Technological Development of the Republic of Serbia [41005]
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In this era of intense study of free radicals and antioxidants, electron paramagnetic resonance (EPR) is arguably the best-suited technique for such research, particularly when considering biochemical and biological systems. No attempt was made to cover all the topics of EPR application but instead attention was restricted to two areas that are both novel and received less attention in previous reviews. In the first section, the application of EPR in assessing the oxidative status of various biological systems, using endogenous stabile paramagnetic species, such as the ascorbyl radical, semiquinone, melanin, and oxidized pigments, is addressed. The second section covers the use of EPR in the emerging field of antioxidant development, using EPR spin-trapping and spin-probing techniques. In both sections, in addition to giving an overview of the available literature, examples (mostly from the authors' recent work) are also presented in sufficient detail to illustrate how to explore the full potential of EPR. This review aims at encouraging biologists, chemists and pharmacologists interested in the redox metabolism of living systems, free radical chemistry or antioxidative properties of new drugs and natural products to take advantage of this technique for their investigations.
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