Journal
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Volume 74, Issue 4, Pages 367-377Publisher
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC0904367D
Keywords
olive leaf extract; phenols; flavonoids; tannins; gastroprotection
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Funding
- Ministry of Science and Technological Development, Republic of Serbia [20137]
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Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenine-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity or the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg(-1)) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.
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