Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 95, Issue 5, Pages 991-999Publisher
WILEY
DOI: 10.1002/jsfa.6778
Keywords
diabetes; mango peel; antioxidant enzymes; streptozotocin induced diabetes; oxidative stress
Funding
- Indian Council of Medical Research, New Delhi
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BACKGROUNDIn the present study, the composition of mango peel powder (MPP) collected from the mango pulp industry was determined and the effect of MPP on ameliorating diabetes and its associated complications was studied. RESULTSMango peel was rich in polyphenols, carotenoids and dietary fibre. Peel extract contained various bioactive compounds and was found to be rich in soluble dietary fibre. Peel extract exhibited antioxidant properties and protected against DNA damage. Therefore, the effect of peel on ameliorating diabetes was investigated in a rat model of diabetes. A significant increase in urine sugar, urine volume, fasting blood glucose, total cholesterol, triglycerides and low density lipoprotein, and decrease in high density lipoprotein were observed in the rats; however, these parameters were ameliorated in diabetic rats fed with diet supplemented with mango peel at 5% and 10% levels in basal diet. Treatment of diabetic rats with MPP increased antioxidant enzyme activities and decreased lipid peroxidation in plasma, kidney and liver compared to untreated diabetic rats. Glomerular filtration rate and microalbuminuria levels were ameliorated in MPP treated diabetic group. CONCLUSIONSMango peel, a by-product, can be used as an ingredient in functional and therapeutic foods. (c) 2014 Society of Chemical Industry
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