Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 94, Issue 8, Pages 1693-1700Publisher
WILEY
DOI: 10.1002/jsfa.6534
Keywords
Humulus lupulus L; hops; phenolic composition; antioxidant activity; antimutagenic activity; proanthocyanidins
Funding
- National Natural Science Foundation of China [31171748]
- Key Technology R&D Program of Shanxi Province [20090321097, 20110321078]
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BACKGROUNDHops (Humulus lupulus L.) contain 40-140mgg(-1) polyphenols. The objective of this study was to determine the phenolic composition of a high-purity (total phenolic content=887mgg(-1)) hop polyphenol extract (HPE) and evaluate its antioxidant activities in vivo and in vitro and its antimutagenic activity. The antioxidant activity of HPE was compared with the activity of green tea polyphenols. RESULTSThe phenolic compositions of HPE were more than 55% proanthocyanidins and more than 28% flavonoid glycosides. In vitro, HPE effectively scavenged ,-diphenyl--picrylhydrazyl, hydroxyl and superoxide anion radicals, and inhibited DNA oxidative damage. In vivo, oral HPE at a polyphenol dose of 200-800mgkg(-1) body weight significantly prevented a bromobenzene-induced decrease in liver superoxide dismutase and glutathione peroxidase activity, and decreased levels of liver thiobarbituric acid reactive substances in bromobenzene-treated mice. An oral dose of 20-80mgkg(-1) body weight HPE significantly reduced the frequency of bone marrow micronuclei induced by cyclophosphamide. The antioxidant activities of hop polyphenols in vitro and in vivo were higher than green tea polyphenols at the same concentration. CONCLUSIONHop polyphenols had the same or higher antioxidant activity than tea polyphenols. Hop polyphenols might be useful as natural antioxidants and antimutagens. (c) 2013 Society of Chemical Industry
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