Journal
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY
Volume 76, Issue 1, Pages 297-318Publisher
WILEY-BLACKWELL
DOI: 10.1111/rssb.12028
Keywords
False discovery rate; Familywise error rate; Hierarchical testing; Multiple testing; Selective inference
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Funding
- European Research Council under EC-EP7 European Research Council [PSARPS-297519]
- US Department of Defense [W81XWH-11-2-008]
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In many complex multiple-testing problems the hypotheses are divided into families. Given the data, families with evidence for true discoveries are selected, and hypotheses within them are tested. Neither controlling the error rate in each family separately nor controlling the error rate over all hypotheses together can assure some level of confidence about the filtration of errors within the selected families. We formulate this concern about selective inference in its generality, for a very wide class of error rates and for any selection criterion, and present an adjustment of the testing level inside the selected families that retains control of the expected average error over the selected families.
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