Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 11, Issue 99, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsif.2014.0101
Keywords
interfacial properties; gradient coating; polyamide; nano-hydroxyapatite; osteogenesis
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Funding
- 863 National Key Project [2011AA030102]
- Natural Science Foundation of China [31370971]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2013111]
- Natural Science Foundation of Shanxi Province [2013021014-2, 2013021003-1, 2013021013-5]
- Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi (OIT)
- Program for the Young Teams of Taiyuan University of Technology [2013T066]
- Taiyuan University of Technology Talents Fund
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Fabrication of bioactive and mechanical matched bone substitutes is crucial for clinical application in bone defects repair. In this study, nano-hydroxyapatite/polyamide (nHA/PA) composite was coated on injection-moulded PA by a chemical corrosion and phase-inversion technique. The shear strength, gradient composition and pore structure of the bioactive coatingwere characterized. Osteoblast-like MG63 cells were cultured on pure PA and composite-coated PA samples. The cells' adhesion, spread and proliferation were determined using MTT assay and microscopy. The results confirm that the samples with the nHA/PA composite coating have better cytocompatibility and have no negative effects on cells. To investigate the in vivo biocompatibility, both pure PA and composite-coated PA cylinders were implanted in the trochlea of rabbit femurs and studied histologically, and the bonding ability with bone were determined using push-out tests. The results show that composite-coated implants exhibit better biocompatibility and the shear strength of the composite-coated implants with host bone at 12 weeks can reach 3.49 +/- 0.42 MPa, which is significantly higher than that of pure PA implants. These results indicate that composite-coated PA implants have excellent biocompatibility and bonding abilities with host bone and they have the potential to be applied in repair of bone defects.
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