Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 9, Issue 70, Pages 801-816Publisher
ROYAL SOC
DOI: 10.1098/rsif.2011.0823
Keywords
mass spectrometry; ion mobility; protein assembly; non-covalent complex; hybrid structural biology
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Funding
- Wellcome Trust
- Royal Society
- BBSRC [BB/J018082/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J018082/1] Funding Source: researchfish
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Mass spectrometry (MS) is a recognized approach for characterizing proteins and the complexes they assemble into. This application of a long-established physico-chemical tool to the frontiers of structural biology has stemmed from experiments performed in the early 1990s. While initial studies focused on the elucidation of stoichiometry by means of simple mass determination, developments in MS technology and methodology now allow researchers to address questions of shape, inter-subunit connectivity and protein dynamics. Here, we chart the remarkable rise of MS and its application to biomolecular complexes over the last two decades.
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