Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 9, Issue 75, Pages 2653-2666Publisher
ROYAL SOC
DOI: 10.1098/rsif.2012.0220
Keywords
protein interaction networks; graph spectra; approximate Bayesian computation; network evolution; sequential Monte Carlo
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Funding
- BBSRC [BB/F005210/2]
- Royal Society
- Biotechnology and Biological Sciences Research Council [BB/F005210/2, BB/F005210/1, BB/F013566/1] Funding Source: researchfish
- BBSRC [BB/F005210/1, BB/F005210/2, BB/F013566/1] Funding Source: UKRI
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We present an analysis of protein interaction network data via the comparison of models of network evolution to the observed data. We take a Bayesian approach and perform posterior density estimation using an approximate Bayesian computation with sequential Monte Carlo method. Our approach allows us to perform model selection over a selection of potential network growth models. The methodology we apply uses a distance defined in terms of graph spectra which captures the network data more naturally than previously used summary statistics such as the degree distribution. Furthermore, we include the effects of sampling into the analysis, to properly correct for the incompleteness of existing datasets, and have analysed the performance of our method under various degrees of sampling. We consider a number of models focusing not only on the biologically relevant class of duplication models, but also including models of scale-free network growth that have previously been claimed to describe such data. We find a preference for a duplication-divergence with linear preferential attachment model in the majority of the interaction datasets considered. We also illustrate how our method can be used to perform multi-model inference of network parameters to estimate properties of the full network from sampled data.
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