Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 6, Issue 34, Pages 463-469Publisher
ROYAL SOC
DOI: 10.1098/rsif.2008.0344
Keywords
associative learning; Hebbian learning; single-celled organism; plasmid; synthetic biology
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Funding
- EU [12789]
- MRC [MC_U117573805] Funding Source: UKRI
- Medical Research Council [MC_U117573805] Funding Source: researchfish
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We demonstrate how a single-celled organism could undertake associative learning. Although to date only one previous study has found experimental evidence for such learning, there is no reason in principle why it should not occur. We propose a gene regulatory network that is capable of associative learning between any pre-specified set of chemical signals, in a Hebbian manner, within a single cell. A mathematical model is developed, and simulations show a clear learned response. A preliminary design for implementing this model using plasmids within Escherichia coli is presented, along with an alternative approach, based on double-phosphorylated protein kinases.
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