Journal
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
Volume 15, Issue 4, Pages 580-584Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1470320313510583
Keywords
ABO; angiotensin-converting enzyme activity; rs495828; polymorphism
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Funding
- Catalonia Ministry of Innovation, Universities and Enterprise (DIUE) [2009SGR1501]
- 'Sara Borrell' contract from the Spanish Ministry of Health, Instituto de Salud Carlos III (Fondo de Investigacion Sanitaria (FIS) [CD09/00296]
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Introduction: ABO rs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABO rs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied. Subjects and methods: We genotyped 168 subjects for rs495828. ACE plasma activity and ABO histo-blood group were measured in all minor allele homozygous subjects (TT) that agreed to participate in the study (n=8) and in age- and gender-matched heterozygous subjects (GT; n=8) and major allele homozygous subjects (GG; n=8). Results: A non-significant trend was found in ACE activity among rs495828 genotype groups; however the polymorphism was significantly associated with ABO phenotype (p=0.007), which in turn was associated with ACE activity (p=0.029). Conclusion: These results provide new evidence for the ABO-ACE relationship. Although the genetic marker studied here may be involved somehow, ABO phenotype is shown to be a better predictor of ACE plasma activity.
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