Journal
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
Volume 18, Issue 3, Pages 220-231Publisher
WILEY
DOI: 10.1111/jns5.12035
Keywords
functional recovery; nerve injury; nerve regeneration; skilled locomotion; transgenic rat
Categories
Funding
- Canadian Institute of Health Research (CIHR)
- Canadian Foundation for Innovation (CFI)
- American College of Surgeons
- Plastic Surgery Foundation (PSF)
- IAMGOLD Corporation
- Hospital for Sick Children RESTRACOMP program
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Transgenic mice have been previously used to assess nerve regeneration following peripheral nerve injury. However, mouse models are limited by their small caliber nerves, short nerve lengths, and their inability to fully participate during behavioral assessments. The transgenic Thy1GFP rat is a novel transgenic rat model designed to assess regeneration following peripheral nerve injury. However, return of functional and behavioral recovery following nerve injury has not yet been evaluated in these rats. In this study, we ask whether differences in anatomy, recovery of locomotion, myological, and histomorphological measures exist between transgenic Thy1GFP rats when compared to wild type (WT) Sprague Dawley rats following unilateral sciatic nerve injury. We found that both motor and sensory neuronal architecture, overground and skilled locomotion, muscle force, motor unit number estimation (MUNE) and wet muscle weights, and histomorphometric assessments are similar between both genetic phenotypes. Overall, these data support the use of the transgenic Thy1-GFP rat in experiments assessing functional and behavioral recovery following nerve injury and repair.
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