Journal
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
Volume 25, Issue 4, Pages 938-946Publisher
OPTICAL SOC AMER
DOI: 10.1364/JOSAA.25.000938
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Funding
- NHLBI NIH HHS [R01 HL55686, HL63953, R01 HL055686] Funding Source: Medline
- NIAMS NIH HHS [R01 AR046996, R01 AR046996-07, R01 AR46996, R01 AR044812-10, R01 AR44812, R01 AR044812] Funding Source: Medline
- NIBIB NIH HHS [R01 EB02638, R01 EB002638-07, R01 EB002638, R01 EB000419] Funding Source: Medline
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Increasing penetration remains one of the most important issues in optical coherence tomography (OCT) research, which we achieved with a parallel ultrasound beam. In addition to qualitative improvements of tissue imaging, quantitative improvements in resolution of up to 28% +/- 2% was noted. At lower frequencies and energies the improvement occurred primarily by altering the detection of multiply scattered light (photon-phonon interaction), which was substantially greater in solids than in liquids (even though the liquid had the higher scattering coefficient). In conclusion, the use of an ultrasound beam with OCT appears the most effective means to date for increasing imaging penetration. (C) 2008 Optical Society of America.
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