Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 337, Issue 1-2, Pages 156-161Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2013.11.041
Keywords
Dementia; Homocysteine; Late Onset Alzheimer's Disease; Oxidative stress; Uric acid; Vascular Dementia
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Funding
- University of Ferrara
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This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral markers. Serum levels of hydroperoxides, homocysteine, advanced oxidation protein products, uric add, thiols, and total and residual antioxidant power were assessed in 103 mild cognitive impairment (MCI), 89 LOAD, 54 VAD patients and 48 Controls. Compared with Controls, a similar oxidative unbalance (high hydroperoxides and low residual antioxidant power) was observed in MCI, LOAD and, although less pronounced, VAD. Moreover, individuals with simultaneously high levels of homocysteine and uric acid, both well-known risk factors for cardiovascular disease, had a high probability to be affected by VAD (O.R.:10.50; 95% C.I.: 2.33-47.2), but not LOAD (O.R.: 3.0; 95% C.I.:0.86-10.76) compared with individuals with normal values. Our data suggest that, although they might share a common. OxS-related pathogenesis, VAD and LOAD might maintain some distinctive features, with a predominance of vascular component in VAD compared with LOAD. (C) 2013 Elsevier B.V. All rights reserved.
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