Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 333, Issue 1-2, Pages 55-59Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2012.12.014
Keywords
Multiple sclerosis; Experimental autoimmune encephalomyelitis; Astroglia
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Funding
- Shriners Hospitals for Children
- National Multiple Sclerosis Foundation
- US Army Medical Research
- NINDS
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Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative disorder that, in its' pathological features, strongly resembles multiple sclerosis. (C) 2012 Elsevier B.V. All rights reserved.
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