Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 335, Issue 1-2, Pages 228-230Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2013.09.034
Keywords
Varicella zoster virus; Temporal artery; Giant cell arteritis; Temporal arteritis; Vasculopathy; Stroke
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Funding
- National Institutes of Health [NS067070, AG006127, AG032958]
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We recently detected varicella zoster virus (VZV) in the temporal arteries (TA) of 5/24 patients with clinically suspect giant cell arteritis (GCA) whose TAs were GCA-negative pathologically; in those GCA-negative, VZV + TAs, virus antigen predominated in the arterial adventitia, but without medial necrosis and multinucleated giant cells [1]. During our continuing search for VZV antigen in GCA-negative TAs, in the TA of one subject, we found abundant VZV antigen, as well as VZV DNA, in multiple regions (skip areas) of the TA spanning 350 mu m, as well as in skeletal muscle adjacent to the infected TA. Additional pathological analysis of sections adjacent to those containing viral antigen revealed inflammation involving the arterial media and abundant multinucleated giant cells characteristic of GCA. Detection of VZV in areas of the TA with pathological features of GCA warrants further correlative pathological-virological analysis of VZV in GCA. (c) 2013 Elsevier B.V. All rights reserved.
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