Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 325, Issue 1-2, Pages 180-182Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2012.12.021
Keywords
Varicella zoster virus; Ischemic optic neuropathy; Temporal arteritis
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Funding
- Public Health Service from the National Institutes of Health [NS067070, AG006127, AG032958]
- Guthy Jackson Charitable Foundation
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We describe a 54-year-old diabetic woman who developed ischemic optic neuropathy followed by acute retinal necrosis and multiple areas of focal venous beading. Vitreous fluid contained amplifiable VZV DNA but not HSV-1, CMV or toxoplasma DNA. The clinical presentation was remarkable for jaw claudication and intermittent scalp pain, prompting a temporal artery biopsy that was pathologically negative for giant cell arteritis, but notable for VZV antigen. The current case adds to the clinical spectrum of multifocal VZV vasculopathy. The development of acute VZV retinal necrosis after ischemic optic neuropathy supports the notion that vasculitis is an important additional mechanism in the development of VZV retinal injury. (C) 2013 Elsevier B.V. All rights reserved.
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