Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 326, Issue 1-2, Pages 53-58Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2013.01.011
Keywords
CSF chemokines; Neuroblastoma; Neuroinflammation; Opsoclonus-myoclonus; Paraneoplastic disorders
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Funding
- Thrasher Research Fund [02826-2]
- Spastic Paralysis Research Foundation (Illinois-Eastern Iowa District of Kiwanis International)
- Chicago Institute of Neurosurgery and Neuroresearch
- Ronald McDonald House Charities of Central Illinois
- McElroy Charitable Trust
- Questcor Pharmaceuticals (Union City, CA)
- Genentech/Biogen IDEC (South San Francisco/San Diego, CA)
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Objective: To test for hypothesized disease- and treatment-induced changes in cytokines and adhesion molecules in children with opsoclonus-myoclonus syndrome (OMS). Methods: Multiplex bead assay technology was used for simultaneous measurement of 34 soluble cytokines in cerebrospinal fluid (CSF) and serum. Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were measured by ELISA. In total, there were 388 children (239 OMS, 114 controls, and 35 other inflammatory neurological disorders (OIND)). Results: In untreated OMS, mean CSF IL-6 was elevated 2.3-fold, but 67-fold in OIND, without significant differences in other CSF cytokines. Mean serum concentrations of sIL-2Ra (+50%) and CXCL1 (+70%) (p<0.0001) were also raised. CSF CCL5 was more often detected in untreated OMS than controls (p = 0.005), as was serum CCL11 and IL-13 in treated OMS. Mean CSF CCL4 and IL-1Ra were selectively higher in IVIg-treated OMS (p <= 0.0001). CSF sICAM-1 was elevated only in OIND (3.3-fold); serum sICAM-1 was higher in untreated OMS (+21%); and sVCAM-1 was not affected. No correlations with OMS severity or duration were identified. Conclusions: Novel cytokine, cytokine antagonist, and soluble adhesion molecule abnormalities due to OMS or treatment were found. However, the normality of much of the data strengthens previous findings implicating B cell mechanisms. (c) 2013 Elsevier B.V. All rights reserved.
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